NanoRoomba: Cellular uptake and durotaxis on ‘’soft and rigid‘’ nanoparticle carpet

Understanding the effect of nanoparticle stiffness on cellular mechanics and durotaxis

Project leader: A. Fink, B. Rothen-Rutishauser

Team: E. Dufresne, A. Radenovic, C. Weder, M. Lattuada

As nanoparticles become more prevalent in both consumer products and biomedical applications, it is therefore necessary to understand how particles can affect cellular mechanics and migration. In this project we will study the effect of nanoparticle properties, specifically particle stiffness, on cellular mechanics and durotaxis, a form of cellular migration dictated by rigidity gradients on the substrate cells interact with.

Main investigator

Involved people