Person | Bioinspired Materials NCCR | Université de Fribourg

ACUNA Guillermo

Professor, Research group ACUÑA

Department of Physics University of Fribourg Ch. du Musée 3 CH-1700 Fribourg Switzerland

Email:	guillermo.acuna@unifr.ch
Website:	https://www3.unifr.ch/phys/en/research/groups/acuna/

Projects lead

Bioinspired DNA self‐assembly of nanophotonic devices

Folding DNA to fabricate optical nano-antennas for advanced diagnostics technologies

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Bottom up meets top down: Controlling assembly from mm to nm

Assembling nano-sized building blocks into functional metasurfaces

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Projects team

Detection of circulating tumor cells by surface enhanced Raman scattering using DNA based systems as signal amplifier

Towards ultrasensitive CTC detection

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New opportunities for tuning colloidal crystals using nanorattles

Assembling nanorattles into structures with hierarchical levels of order and/or disorder

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Complex disordered photonic architectures by self-assembly

Exploring new approaches for the synthesis of disordered photonic materials

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DNA Origami-based sensor for the multiplex detection of mRNA in cancer

Towards ultra-sensitive cancer diagnosis

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Publications

Directing single-molecule emission with DNA origami-assembled optical antennas
Hübner Kristina, Pilo-Pais Mauricio, Selbach Florian, Liedl Tim, Tinnefeld Philip, Stefani Fernando D., Acuna Guillermo P.
Nano Letters (2019)

DNA origami as emerging technology for the engineering of fluorescent and plasmonic-based biosensors
Loretan Morgane, Domljanovic Ivana, Lakatos Mathias, Rüegg Curzio, Acuna Guillermo P.
Materials (2020)

Three-dimensional total-internal reflection fluorescence nanoscopy with nanometric axial resolution by photometric localization of single molecules
Szalai Alan M., Siarry Bruno, Lukin Jerónimo, Williamson David J., Unsain Nicolás, Cáceres Alfredo, Pilo-Pais Mauricio, Acuna Guillermo, Refojo Damián, Owen Dylan M., Simoncelli Sabrina, Stefani Fernando D.
Nature Communications (2021)

Recent advances in plasmonic nanocavities for single-molecule spectroscopy
Maccaferri Nicolò, Barbillon Grégory, Koya Alemayehu Nana, Lu Guowei, Acuna Guillermo P., Garoli Denis
Nanoscale Advances (2020)

Addressable nanoantennas with cleared hotspots for single-molecule detection on a portable smartphone microscope
Trofymchuk Kateryna, Glembockyte Viktorija, Grabenhorst Lennart, Steiner Florian, Vietz Carolin, Close Cindy, Pfeiffer Martina, Richter Lars, Schütte Max L., Selbach Florian, Yaadav Renukka, Zähringer Jonas, Wei Qingshan, Ozcan Aydogan, Lalkens Birka, Acuna Guillermo P., Tinnefeld Philip
Nature Communications (2021)

An alternative to MINFLUX that enables nanometer resolution in a confocal microscope
Masullo Luciano A., Szalai Alan M., Lopez Lucía F., Pilo-Pais Mauricio, Acuna Guillermo P., Stefani Fernando D.
Light: Science & Applications (2022)

DNA-Templated Ultracompact Optical Antennas for Unidirectional Single-Molecule Emission
Zhu Fangjia, Sanz-Paz María, Fernández-Domínguez Antonio I., Zhuo Xiaolu, Liz-Marzán Luis M., Stefani Fernando D., Pilo-Pais Mauricio, Acuna Guillermo P.
Nano Letters (2022)

DNA Self-Assembly of Single Molecules with Deterministic Position and Orientation
Adamczyk Aleksandra K., Huijben Teun A. P. M., Sison Miguel, Di Luca Andrea, Chiarelli Germán, Vanni Stefano, Brasselet Sophie, Mortensen Kim I., Stefani Fernando D., Pilo-Pais Mauricio, Acuna Guillermo P.
ACS Nano (2022)

Optical Ultracompact Directional Antennas Based on a Dimer Nanorod Structure
Zhu Fangjia, Sanz-Paz María, Fernández-Domínguez Antonio I., Pilo-Pais Mauricio, Acuna Guillermo P.
Nanomaterials (2022)

DNA origami book biosensor for multiplex detection of cancer-associated nucleic acids
Domljanovic Ivana, Loretan Morgane, Kempter Susanne, Acuna Guillermo P., Kocabey Samet, Ruegg Curzio
Nanoscale (2022)

Reconfigurable chirality with achiral excitonic materials in the strong-coupling regime
Stamatopoulou P. Elli, Droulias Sotiris, Acuna Guillermo P., Mortensen N. Asger, Tserkezis Christos
Nanoscale (2022)

Ultrasensitive and multiplexed miRNA detection system with DNA-PAINT
Kocabey Samet, Chiarelli Germán, Acuna Guillermo P., Ruegg Curzio
Biosensors and Bioelectronics (2022)

Nanometer Resolution Imaging and Tracking of Single Fluorophores by Sequential Structured Illumination
Zdańkowski Piotr, Lopez Lucía F., Acuna Guillermo P., Stefani Fernando D.
ACS Photonics (2022)

Gold Nanorod DNA Origami Antennas for 3 Orders of Magnitude Fluorescence Enhancement in NIR
Trofymchuk Kateryna, Kołątaj Karol, Glembockyte Viktorija, Zhu Fangjia, Acuna Guillermo P., Liedl Tim, Tinnefeld Philip
ACS Nano (2023)

Super‐Resolved FRET Imaging by Confocal Fluorescence‐Lifetime Single‐Molecule Localization Microscopy
Zaza Cecilia, Chiarelli Germán, Zweifel Ludovit P., Pilo‐Pais Mauricio, Sisamakis Evangelos, Barachati Fabio, Stefani Fernando D., Acuna Guillermo P.
Small Methods (2023)

Fabrication of 3D Oriented MOF Micropatterns with Anisotropic Fluorescent Properties
Velásquez‐Hernández Miriam de J., Linares‐Moreau Mercedes, Brandner Lea A., Marmiroli Benedetta, Barella Mariano, Acuna Guillermo P., Zilio Simone Dal, Verstreken Margot F. K., Kravchenko Dmitry E., Linder‐Patton Oliver M., Evans Jack D., Wiltsche Helmar, Carraro Francesco, Wolinski Heimo, Ameloot Rob, Doonan Christian, Falcaro Paolo
Advanced Materials (2023)

DNA Origami Assembled Nanoantennas for Manipulating Single-Molecule Spectral Emission
Sanz-Paz María, Zhu Fangjia, Bruder Nicolas, Kołątaj Karol, Fernández-Domínguez Antonio I., Acuna Guillermo P.
Nano Letters (2023)

Unidirectional Meta-Emitters Based on the Kerker Condition Assembled by DNA Origami
Yeşilyurt Ayşe Tuğça Mina, Sanz-Paz Maria, Zhu Fangjia, Wu Xiaofei, Sunil Karthika Suma, Acuna Guillermo P., Huang Jer-Shing
ACS Nano (2023)

Universal Click-Chemistry Approach for the DNA Functionalization of Nanoparticles
Siegel Nicole, Hasebe Hiroaki, Chiarelli Germán, Garoli Denis, Sugimoto Hiroshi, Fujii Minoru, Acuna Guillermo P., Kołątaj Karol
Journal of the American Chemical Society (2024)

ACUNA Guillermo

Bioinspired DNA self‐assembly of nanophotonic devices

Bottom up meets top down: Controlling assembly from mm to nm

Detection of circulating tumor cells by surface enhanced Raman scattering using DNA based systems as signal amplifier

New opportunities for tuning colloidal crystals using nanorattles

Complex disordered photonic architectures by self-assembly

DNA Origami-based sensor for the multiplex detection of mRNA in cancer