Person | Bioinspired Materials NCCR | Université de Fribourg

BOURQUIN Carole

Alumni

Professor, Research group BOURQUIN

Immunopharmacology of Cancer Pharmaceutical Sciences University of Geneva CMU-Rue Michel-Servet 1 1211 Genève 4 Switzerland

Email:	carole.bourquin@unige.ch
Website:	epgl.unige.ch/immunopharmaco/

Projects lead

Controlled activation of cancer-associated immune cells by stimuli-responsive nanoparticles

Active between 01.06.2014 and 31.05.2018

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Publications

Engineered hybrid spider silk particles as delivery system for peptide vaccines
Lucke Matthias, Mottas Inès, Herbst Tina, Hotz Christian, Römer Lin, Schierling Martina, Herold Heike M., Slotta Ute, Spinetti Thibaud, Scheibel Thomas, Winter Gerhard, Bourquin Carole, Engert Julia
Biomaterials (2018)

Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulation
Widmer Jérôme, Thauvin Cédric, Mottas Inès, Nguyen Van Nga, Delie Florence, Allémann Eric, Bourquin Carole
International Journal of Pharmaceutics (2018)

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade
Secondini Chiara, Coquoz Oriana, Spagnuolo Lorenzo, Spinetti Thibaud, Peyvandi Sanam, Ciarloni Laura, Botta Francesca, Bourquin Carole, Rüegg Curzio
OncoImmunology (2017)

A rapid screening method to evaluate the impact of nanoparticles on macrophages
Mottas Inès, Milosevic Ana, Petri-Fink Alke, Rothen-Rutishauser Barbara, Bourquin Carole
Nanoscale (2017)

Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells
Priebe Magdalena, Widmer Jérôme, Suhartha Löwa Nina, Abram Sarah-Luise, Mottas Inès, Woischnig Anne-Kathrin, Brunetto Priscilla S., Khanna Nina, Bourquin Carole, Fromm Katharina M.
Nanomedicine: Nanotechnology, Biology and Medicine (2017)

Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses
Hotz Christian, Treinies Marina, Mottas Ines, Rötzer Laurin C., Oberson Anne, Spagnuolo Lorenzo, Perdicchio Maurizio, Spinetti Thibaud, Herbst Tina, Bourquin Carole
OncoImmunology (2016)

TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function
Spinetti Thibaud, Spagnuolo Lorenzo, Mottas Inès, Secondini Chiara, Treinies Marina, Rüegg Curzio, Hotz Christian, Bourquin Carole
OncoImmunology (2016)

Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery
Heidegger Simon, Gößl Dorothée, Schmidt Alexandra, Niedermayer Stefan, Argyo Christian, Endres Stefan, Bein Thomas, Bourquin Carole
Nanoscale (2016)

Neonatal immune tolerance induction to allow long-term studies with an immunogenic therapeutic monoclonal antibody in mice
Piccand Matthieu, Bessa Juliana, Schick Eginhard, Senn Claudia, Bourquin Carole, Richter Wolfgang F.
The AAPS Journal (2015)

Mycoplasma hyorhinis-contaminated cell lines activate primary innate immune cells via a protease-sensitive factor
Heidegger Simon, Jarosch Alexander, Schmickl Martina, Endres Stefan, Bourquin Carole, Hotz Christian
PLOS ONE (2015)

Suppression of intratumoral CCL22 by type I interferon inhibits migration of regulatory T cells and blocks cancer progression
Anz D., Rapp M., Eiber S., Koelzer V. H., Thaler R., Haubner S., Knott M., Nagel S., Golic M., Wiedemann G. M., Bauernfeind F., Wurzenberger C., Hornung V., Scholz C., Mayr D., Rothenfusser S., Endres S., Bourquin C.
Cancer Research (2015)

TLR and RLR signaling are reprogrammed in opposite directions after detection of viral infection
Hotz Christian, Roetzer Laurin C., Huber Thomas, Sailer Andreas, Oberson Anne, Treinies Marina, Heidegger Simon, Herbst Tina, Endres Stefan, Bourquin Carole
The Journal of Immunology (2015)

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation
Mottas Inès, Bekdemir Ahmet, Cereghetti Alessandra, Spagnuolo Lorenzo, Yang Yu-Sang Sabrina, Müller Marie, Irvine Darrell J., Stellacci Francesco, Bourquin Carole
Biomaterials (2019)

Bionanomaterials for the delivery of cancer immunotherapy
Bourquin Carole
CHIMIA International Journal for Chemistry (2019)

CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes
Rapp Moritz, Wintergerst Maximilian W.M., Kunz Wolfgang G., Vetter Viola K., Knott Max M.L., Lisowski Dominik, Haubner Sascha, Moder Stefan, Thaler Raffael, Eiber Stephan, Meyer Bastian, Röhrle Natascha, Piseddu Ignazio, Grassmann Simon, Layritz Patrick, Kühnemuth Benjamin, Stutte Susanne, Bourquin Carole, von Andrian Ulrich H., Endres Stefan, Anz David
The Journal of Experimental Medicine (2019)

Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic study
Thauvin Cédric, Widmer Jérôme, Mottas Inès, Hocevar Sandra, Allémann Eric, Bourquin Carole, Delie Florence
European Journal of Pharmaceutics and Biopharmaceutics (2019)

Polymer-coated gold nanospheres do not impair the innate immune function of human B lymphocytes in vitro
Hočevar Sandra, Milošević Ana, Rodriguez-Lorenzo Laura, Ackermann-Hirschi Liliane, Mottas Ines, Petri-Fink Alke, Rothen-Rutishauser Barbara, Bourquin Carole, Clift Martin James David
ACS Nano (2019)

Silver-containing titanium dioxide nanocapsules for combating multidrug-resistant bacteria
Hérault Nelly, Wagner Julia, Abram Sarah-Luise, Widmer Jérôme, Horvath Lenke, Vanhecke Dimitri, Bourquin Carole, Fromm Katharina M
International Journal of Nanomedicine (2020)

HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis
Spagnuolo Lorenzo, Puddinu Viola, Boss Noémie, Spinetti Thibaud, Oberson Anne, Widmer Jerome, Mottas Inès, Hotz Christian, Bianchi Marco E., Uguccioni Mariagrazia, Bourquin Carole
European Journal of Immunology (2021)

Polymer-Coated Gold Nanospheres Do Not Impair the Innate Immune Function of Human B Lymphocytes in Vitro
Hočevar Sandra, Milošević Ana, Rodriguez-Lorenzo Laura, Ackermann-Hirschi Liliane, Mottas Ines, Petri-Fink Alke, Rothen-Rutishauser Barbara, Bourquin Carole, Clift Martin James David
ACS Nano (2019)

BOURQUIN Carole

Controlled activation of cancer-associated immune cells by stimuli-responsive nanoparticles