Person | Bioinspired Materials NCCR | Université de Fribourg

RÜEGG Curzio

Professor, Research group RÜEGG

Department of Medicine University of Fribourg Chemin du Musée 8 CH-1700 Fribourg Switzerland

Email:	curzio.ruegg@unifr.ch
Website:	https://www3.unifr.ch/med/de/research/groups/ruegg/

Projects lead

Trapping cancer cells with self-assembling biomolecules

Mimicking the pathogen-killing mechanism of neutrophil granulocytes to fight cancer metastasis

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Sensoresponsive nanoelements to detect individual cancer cells

Active between 01.06.2014 and 31.05.2018

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Development of Tumor/Immune Cell Organoid Model

A tumoroid culture system to study the role of inflammation in cancer dormancy vs progression

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Projects team

Self-assembly of DNA- or RNA-triggered ion channels for targeted cell killing and nanopore sensing

Drawing inspiration from nature to kill cancer cells and pathogens selectively

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Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

Sensing and enhancing nanoparticle uptake

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Development of a Microfluidic Platform

Development of a Microfluidic Organoid Culture Platform

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DNA Origami-based sensor for the multiplex detection of mRNA in cancer

Towards ultra-sensitive cancer diagnosis

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Publications

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade
Secondini Chiara, Coquoz Oriana, Spagnuolo Lorenzo, Spinetti Thibaud, Peyvandi Sanam, Ciarloni Laura, Botta Francesca, Bourquin Carole, Rüegg Curzio
OncoImmunology (2017)

The matricellular protein CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and suppressing anoikis
Huang Yu-Ting, Lan Qiang, Lorusso Girieca, Duffey Nathalie, Rüegg Curzio
Oncotarget (2016)

TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function
Spinetti Thibaud, Spagnuolo Lorenzo, Mottas Inès, Secondini Chiara, Treinies Marina, Rüegg Curzio, Hotz Christian, Bourquin Carole
OncoImmunology (2016)

Not just fundamental research: Education, Equal Opportunities, Knowledge and Technology Transfer, and Communication at the NCCR Bio-Inspired Materials
Capper Scott, Haskal Eliav, Kilbinger Andreas, de Espinosa Lucas Montero, Rothen-Rutishauser Barbara, Rüegg Curzio, Weder Christoph
CHIMIA International Journal for Chemistry (2019)

A bio-inspired amplification cascade for the detection of rare cancer cells
Rüegg Curzio, Reis Corine, Rafiee Sarah, Rodriguez-Lorenzo Laura, List Jonathan, Rothen-Rutishauser Barbara, Mayer Michael, Petri-Fink Alke
CHIMIA International Journal for Chemistry (2019)

Are integrins still practicable targets for anti-cancer therapy?
Alday-Parejo , Stupp , Rüegg
Cancers (2019)

Detection of HER2+ breast cancer cells using bioinspired DNA‐based signal amplification
Rafiee Sarah, Kocabey Samet, Mayer Michael, List Jonathan, Ruegg Curzio
ChemMedChem (2020)

DNA origami as emerging technology for the engineering of fluorescent and plasmonic-based biosensors
Loretan Morgane, Domljanovic Ivana, Lakatos Mathias, Rüegg Curzio, Acuna Guillermo P.
Materials (2020)

Membrane-interacting DNA nanotubes induce cancer cell death
Kocabey Samet, Ekim Kocabey Aslihan, Schneiter Roger, Rüegg Curzio
Nanomaterials (2021)

A rational and iterative process for targeted nanoparticle design and validation
Rodriguez-Lorenzo Laura, Rafiee Sarah D., Reis Corine, Milosevic Ana, Moore Thomas L., Balog Sandor, Rothen-Rutishauser Barbara, Ruegg Curzio, Petri-Fink Alke
Colloids and Surfaces B: Biointerfaces (2018)

A Bio-Inspired Amplification Cascade for the Detection of Rare Cancer Cells
Rüegg Curzio, Reis Corine, Rafiee Sarah, Rodriguez-Lorenzo Laura, List Jonathan, Rothen-Rutishauser Barbara, Mayer Michael, Petri-Fink Alke
CHIMIA International Journal for Chemistry (2019)

A rational and iterative process for targeted nanoparticle design and validation
Rodriguez-Lorenzo Laura, Rafiee Sarah D., Reis Corine, Milosevic Ana, Moore Thomas L., Balog Sandor, Rothen-Rutishauser Barbara, Ruegg Curzio, Petri-Fink Alke
Colloids and Surfaces B: Biointerfaces (2018)

Polymersomes‐mediated Delivery of CSF1R Inhibitor to Tumor Associated Macrophages Promotes M2 to M1‐like Macrophage Repolarization
Rodriguez‐Perdigon Manuel, Jimaja Sètuhn, Haen Laetitia, Bruns Nico, Rothen‐Rutishauser Barbara, Rüegg Curzio
Macromolecular Bioscience (2022)

Natural and Modified Oligonucleotide Sequences Show Distinct Strand Displacement Kinetics and These Are Affected Further by Molecular Crowders
Domljanovic Ivana, Ianiro Alessandro, Rüegg Curzio, Mayer Michael, Taskova Maria
Biomolecules (2022)

DNA origami book biosensor for multiplex detection of cancer-associated nucleic acids
Domljanovic Ivana, Loretan Morgane, Kempter Susanne, Acuna Guillermo P., Kocabey Samet, Ruegg Curzio
Nanoscale (2022)

Ultrasensitive and multiplexed miRNA detection system with DNA-PAINT
Kocabey Samet, Chiarelli Germán, Acuna Guillermo P., Ruegg Curzio
Biosensors and Bioelectronics (2022)

Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2+ breast cancer spheroid model
Rodriguez-Perdigon Manuel, Haeni Laetitia, Rothen-Rutishauser Barbara, Rüegg Curzio
Frontiers in Bioengineering and Biotechnology (2023)

RÜEGG Curzio

Trapping cancer cells with self-assembling biomolecules

Sensoresponsive nanoelements to detect individual cancer cells

Development of Tumor/Immune Cell Organoid Model

Self-assembly of DNA- or RNA-triggered ion channels for targeted cell killing and nanopore sensing

Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

Development of a Microfluidic Platform

DNA Origami-based sensor for the multiplex detection of mRNA in cancer