Person | Bioinspired Materials NCCR | Université de Fribourg

ROTHEN Barbara

Co-leader Module 3, Professor, Research group ROTHEN-RUTISHAUSER

Adolphe Merkle Institute Chemin des Verdiers 4 CH-1700 Fribourg Switzerland

Office:	B314
Phone:	+41 26 300 9502
Email:	barbara.rothen@unifr.ch
Website:	https://www.ami.swiss/bionanomaterials/en/
	0000-0002-7805-9366

Projects lead

NanoRoomba: Cellular uptake and durotaxis on ‘’soft and rigid‘’ nanoparticle carpet

Understanding the effect of nanoparticle stiffness on cellular mechanics and durotaxis

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Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

Sensing and enhancing nanoparticle uptake

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Magneto-responsive cell culture substrates that can be modulated in situ

Active between 01.06.2014 and 31.05.2018

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Intelligent nanomaterials to reveal and control their behavior in complex media, at biointerface and in cells

Active between 01.06.2014 and 31.05.2018

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Development of Tumor/Immune Cell Organoid Model

A tumoroid culture system to study the role of inflammation in cancer dormancy vs progression

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Projects team

Characterizing nanoparticle-membrane interactions via molecular dynamics simulations

Investigating how the surface chemistry of nanoparticles dictates their interaction with cells

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Fluorescent nanodiamonds as quantum bio-molecular probes for live cell imaging and sensing

Towards super-resolution imaging in quantum physics and life sciences

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Mechanically responsive and mechanically adapting polymers

Reducing the activation stress threshold of mechanoresponsive materials

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Novel antiviral supramolecular materials

Developping broad-spectrum, low-toxicity and specific virucidal materials

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Self-assembly of DNA- or RNA-triggered ion channels for targeted cell killing and nanopore sensing

Drawing inspiration from nature to kill cancer cells and pathogens selectively

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Trapping cancer cells with self-assembling biomolecules

Mimicking the pathogen-killing mechanism of neutrophil granulocytes to fight cancer metastasis

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Mechanically responsive nanoparticles

Understanding and exploiting the effect of mechanical stress on nanoparticles in biological media

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Development of a Microfluidic Platform

Development of a Microfluidic Organoid Culture Platform

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Development of controlled delivery systems for organ-on-chip devices

Directing the motion of colloidal shuttles with external stimuli

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Nature-inspired nano-interfaces for triggering lipid digestion

Fighting digestion disorders with Nature-inspired nanocarriers

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Dynamic surfaces for tissue engineering and tissue remodeling

Exploring and exploiting cell-nanoparticle interactions to influence cell’s behaviour

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Antiviral Surfaces

Broad-spectrum antiviral coatings for high touch surfaces

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Antimicrobial surfaces

A new approach to antimicrobial surfaces and structural antibiotics

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Publications

A novel sample holder for 4D live cell imaging to study cellular dynamics in complex 3D tissue cultures
Septiadi D., Bourquin J., Durantie E., Petri-Fink A., Rothen-Rutishauser B.
Scientific Reports (2018)

Biodistribution, clearance, and long-term fate of clinically relevant nanomaterials
Bourquin Joël, Milosevic Ana, Hauser Daniel, Lehner Roman, Blank Fabian, Petri-Fink Alke, Rothen-Rutishauser Barbara
Advanced Materials (2018)

Nanoparticle-cell interaction: A cell mechanics perspective
Septiadi Dedy, Crippa Federica, Moore Thomas Lee, Rothen-Rutishauser Barbara, Petri-Fink Alke
Advanced Materials (2018)

Probing nano-scale viscoelastic response in air and in liquid with dynamic atomic force microscopy
Crippa Federica, Thorén Per-Anders, Forchheimer Daniel, Borgani Riccardo, Rothen-Rutishauser Barbara, Petri-Fink Alke, Haviland David B.
Soft Matter (2018)

Lock-in thermography as an analytical tool for magnetic nanoparticles: Measuring heating power and magnetic fields
Monnier Christophe A., Crippa Federica, Geers Christoph, Knapp Evelyne, Rothen-Rutishauser Barbara, Bonmarin Mathias, Lattuada Marco, Petri-Fink Alke
The Journal of Physical Chemistry C (2017)

Biodistribution of single and aggregated gold nanoparticles exposed to the human lung epithelial tissue barrier at the air-liquid interface
Durantie Estelle, Vanhecke Dimitri, Rodriguez-Lorenzo Laura, Delhaes Flavien, Balog Sandor, Septiadi Dedy, Bourquin Joel, Petri-Fink Alke, Rothen-Rutishauser Barbara
Particle and Fibre Toxicology (2017)

Characteristics and properties of nano-LiCoO2 synthesized by pre-organized single source precursors: Li-ion diffusivity, electrochemistry and biological assessment
Brog Jean-Pierre, Crochet Aurélien, Seydoux Joël, Clift Martin J. D., Baichette Benoît, Maharajan Sivarajakumar, Barosova Hana, Brodard Pierre, Spodaryk Mariana, Züttel Andreas, Rothen-Rutishauser Barbara, Kwon Nam Hee, Fromm Katharina M.
Journal of Nanobiotechnology (2017)

Assessing the stability of fluorescently encoded nanoparticles in lysosomes by using complementary methods
Milosevic Ana M., Rodriguez-Lorenzo Laura, Balog Sandor, Monnier Christophe A., Petri-Fink Alke, Rothen-Rutishauser Barbara
Angewandte Chemie International Edition (2017)

In vitro approaches to assess the hazard of nanomaterials
Drasler Barbara, Sayre Phil, Steinhäuser Klaus Günter, Petri-Fink Alke, Rothen-Rutishauser Barbara
NanoImpact (2017)

Form follows function: Nanoparticle shape and its implications for nanomedicine
Kinnear Calum, Moore Thomas L., Rodriguez-Lorenzo Laura, Rothen-Rutishauser Barbara, Petri-Fink Alke
Chemical Reviews (2017)

Taylor dispersion of nanoparticles
Balog Sandor, Urban Dominic A., Milosevic Ana M., Crippa Federica, Rothen-Rutishauser Barbara, Petri-Fink Alke
Journal of Nanoparticle Research (2017)

Cellular shuttles: Monocytes/Macrophages exhibit transendothelial transport of nanoparticles under physiological flow
Moore Thomas L., Hauser Daniel, Gruber Thomas, Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke, Lyck Ruth
ACS Applied Materials & Interfaces (2017)

Quantifying nanoparticle cellular uptake: which method is best?
Drasler Barbara, Vanhecke Dimitri, Rodriguez-Lorenzo Laura, Petri-Fink Alke, Rothen-Rutishauser Barbara
Nanomedicine (2017)

Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field
Crippa Federica, Moore Thomas L., Mortato Mariangela, Geers Christoph, Haeni Laetitia, Hirt Ann M., Rothen-Rutishauser Barbara, Petri-Fink Alke
Journal of Magnetism and Magnetic Materials (2017)

Lock-in thermography as a rapid and reproducible thermal characterization method for magnetic nanoparticles
Lemal Philipp, Geers Christoph, Monnier Christophe A., Crippa Federica, Daum Leopold, Urban Dominic A., Rothen-Rutishauser Barbara, Bonmarin Mathias, Petri-Fink Alke, Moore Thomas L.
Journal of Magnetism and Magnetic Materials (2017)

Assumption-free morphological quantification of single anisotropic nanoparticles and aggregates
Vanhecke Dimitri, Rodríguez-Lorenzo Laura, Kinnear Calum, Durantie Estelle, Rothen-Rutishauser Barbara, Petri-Fink Alke
Nanoscale (2017)

A rapid screening method to evaluate the impact of nanoparticles on macrophages
Mottas Inès, Milosevic Ana, Petri-Fink Alke, Rothen-Rutishauser Barbara, Bourquin Carole
Nanoscale (2017)

Organometallic cobalamin anticancer derivatives for targeted prodrug delivery via transcobalamin-mediated uptake
Rossier Jeremie, Hauser Daniel, Kottelat Emmanuel, Rothen-Rutishauser Barbara, Zobi Fabio
Dalton Transactions (2017)

Measuring the heating power of magnetic nanoparticles: an overview of currently used methods
Lemal Philipp, Geers Christoph, Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke
Materials Today: Proceedings (2017)

Currentin vitroapproaches to assess nanoparticle interactions with lung cells
Fytianos Kleanthis, Drasler Barbara, Blank Fabian, von Garnier Christophe, Seydoux Emilie, Rodriguez-Lorenzo Laura, Petri-Fink Alke, Rothen-Rutishauser Barbara
Nanomedicine (2016)

A lock-in-based method to examine the thermal signatures of magnetic nanoparticles in the liquid, solid and aggregated states
Monnier C. A., Lattuada M., Burnand D., Crippa F., Martinez-Garcia J. C., Hirt A. M., Rothen-Rutishauser B., Bonmarin M., Petri-Fink A.
Nanoscale (2016)

Synthesis, characterization, antibacterial activity and cytotoxicity of hollow TiO2-coated CeO2 nanocontainers encapsulating silver nanoparticles for controlled silver release
Gagnon J., Clift M. J. D., Vanhecke D., Widnersson I. E., Abram S.-L., Petri-Fink A., Caruso R. A., Rothen-Rutishauser B., Fromm K. M.
Journal of Materials Chemistry B (2016)

In vitro-ex vivo model systems for nanosafety assessment
Wick Peter, Chortarea Savvina, Guenat Olivier T., Roesslein Matthias, Stucki Janick D., Hirn Stephanie, Petri-Fink Alke, Rothen-Rutishauser Barbara
European Journal of Nanomedicine (2015)

Thermally reversible self-assembly of nanoparticles via polymer crystallization
Kinnear Calum, Balog Sandor, Rothen-Rutishauser Barbara, Petri-Fink Alke
Macromolecular Rapid Communications (2014)

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages
Kuhn Dagmar A, Vanhecke Dimitri, Michen Benjamin, Blank Fabian, Gehr Peter, Petri-Fink Alke, Rothen-Rutishauser Barbara
Beilstein Journal of Nanotechnology (2014)

In vitro dosimetry of agglomerates
Hirsch V., Kinnear C., Rodriguez-Lorenzo L., Monnier C. A., Rothen-Rutishauser B., Balog S., Petri-Fink A.
Nanoscale (2014)

Magnetoliposomes: opportunities and challenges
Monnier Christophe A., Burnand David, Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke
European Journal of Nanomedicine (2014)

Directed cell growth in multi-zonal scaffolds for cartilage tissue engineering
Camarero-Espinosa Sandra, Rothen-Rutishauser Barbara, Weder Christoph, Foster E. Johan
Biomaterials (2016)

Plasmonic nanoparticles and their characterization in physiological fluids
Urban Dominic A., Rodriguez-Lorenzo Laura, Balog Sandor, Kinnear Calum, Rothen-Rutishauser Barbara, Petri-Fink Alke
Colloids and Surfaces B: Biointerfaces (2016)

Cellular uptake and cell-to-cell transfer of polyelectrolyte microcapsules within a triple co-culture system representing parts of the respiratory tract
Kuhn Dagmar A, Hartmann Raimo, Fytianos Kleanthis, Petri-Fink Alke, Rothen-Rutishauser Barbara, Parak Wolfgang J
Science and Technology of Advanced Materials (2015)

Nanoparticle colloidal stability in cell culture media and impact on cellular interactions
Moore Thomas L., Rodriguez-Lorenzo Laura, Hirsch Vera, Balog Sandor, Urban Dominic, Jud Corinne, Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke
Chemical Society Reviews (2015)

A biological perspective toward the interaction of theranostic nanoparticles with the bloodstream â€“ what needs to be considered?
Clift Martin J. D., DechÃ©zelles Jean-FranÃ§ois, Rothen-Rutishauser Barbara, Petri-Fink Alke
Frontiers in Chemistry (2015)

Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering
Balog S., Rodriguez-Lorenzo L., Monnier C. A., Obiols-Rabasa M., Rothen-Rutishauser B., Schurtenberger P., Petri-Fink A.
Nanoscale (2015)

Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

(2017)

Slow-targeted release of a ruthenium anticancer agent from vitamin B12 functionalized marine diatom microalgae
Delasoie Joachim, Rossier Jérémie, Haeni Laetitia, Rothen-Rutishauser Barbara, Zobi Fabio
Dalton Transactions (2018)

Structure and sedimentation kinetics of dense suspensions of fibroblast cells
Zenuni Arbnor, Zhang Chi, Haeni Laetitia, Rothen-Rutishauser Barbara, Scheffold Frank
CHIMIA International Journal for Chemistry (2019)

Magneto-responsive cell culture substrates that can be modulated in situ
Crippa Federica, Rothen-Rutishauser Barbara, Petri-Fink Alke
CHIMIA International Journal for Chemistry (2019)

Templated assembly of pore-forming peptides in lipid membranes
Fennouri Aziz, List Jonathan, Dupasquier Jessica, Haeni Laetitia, Vanni Stefano, Rothen-Rutishauser Barbara, Mayer Michael
CHIMIA International Journal for Chemistry (2019)

Not just fundamental research: Education, Equal Opportunities, Knowledge and Technology Transfer, and Communication at the NCCR Bio-Inspired Materials
Capper Scott, Haskal Eliav, Kilbinger Andreas, de Espinosa Lucas Montero, Rothen-Rutishauser Barbara, Rüegg Curzio, Weder Christoph
CHIMIA International Journal for Chemistry (2019)

A bio-inspired amplification cascade for the detection of rare cancer cells
Rüegg Curzio, Reis Corine, Rafiee Sarah, Rodriguez-Lorenzo Laura, List Jonathan, Rothen-Rutishauser Barbara, Mayer Michael, Petri-Fink Alke
CHIMIA International Journal for Chemistry (2019)

An atomistic look into bio-inspired nanoparticles and their molecular interactions with cells
Petretto Emanuele, Campomanes Pablo, Stellacci Francesco, Rothen-Rutishauser Barbara, Petri-Fink Alke, Vanni Stefano
CHIMIA International Journal for Chemistry (2019)

Artificial lysosomal platform to study nanoparticle long-term stability
MilosevicAc Ana, Bourquin Joël, Burnand David, Lemal Philipp, Crippa Federica, Monnier Christophe A., Rodriguez-Lorenzo Laura, Petri-Fink Alke, Rothen-Rutishauser Barbara
CHIMIA International Journal for Chemistry (2019)

Polymer-coated gold nanospheres do not impair the innate immune function of human B lymphocytes in vitro
Hočevar Sandra, Milošević Ana, Rodriguez-Lorenzo Laura, Ackermann-Hirschi Liliane, Mottas Ines, Petri-Fink Alke, Rothen-Rutishauser Barbara, Bourquin Carole, Clift Martin James David
ACS Nano (2019)

Polydopamine/Transferrin hybrid nanoparticles for targeted cell-killing
Hauser Daniel, Estermann Manuela, Milosevic Ana, Steinmetz Lukas, Vanhecke Dimitri, Septiadi Dedy, Drasler Barbara, Petri-Fink Alke, Ball Vincent, Rothen-Rutishauser Barbara
Nanomaterials (2018)

Targeting specific membranes with an azide derivative of the pore-forming peptide ceratotoxin A
Mayer Simon Finn, Ducrey Julie, Dupasquier Jessica, Haeni Laetitia, Rothen-Rutishauser Barbara, Yang Jerry, Fennouri Aziz, Mayer Michael
Biochimica et Biophysica Acta (BBA) - Biomembranes (2019)

Lock‐in thermography to analyze plasmonic nanoparticle dispersions
Steinmetz Lukas, Taladriz‐Blanco Patricia, Geers Christoph, Spuch‐Calvar Miguel, Bonmarin Mathias, Balog Sandor, Rothen‐Rutishauser Barbara, Petri‐Fink Alke
Particle & Particle Systems Characterization (2019)

Precision of taylor dispersion
Taladriz-Blanco Patricia, Rothen-Rutishauser Barbara, Petri-Fink Alke, Balog Sandor
Analytical Chemistry (2019)

Nanoparticle administration method in cell culture alters particle-cell interaction
Moore Thomas L., Urban Dominic A., Rodriguez-Lorenzo Laura, Milosevic Ana, Crippa Federica, Spuch-Calvar Miguel, Balog Sandor, Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke
Scientific Reports (2019)

Targeting specific membranes with an azide derivative of the pore-forming peptide ceratotoxin A
Mayer Simon Finn, Ducrey Julie, Dupasquier Jessica, Haeni Laetitia, Rothen-Rutishauser Barbara, Yang Jerry, Fennouri Aziz, Mayer Michael
Biochimica et Biophysica Acta (BBA) - Biomembranes (2019)

Simple and fast evaluation of relaxation parameters of magnetic nanoparticles
Lemal Philipp, Balog Sandor, Ackermann-Hirschi Liliane, Taladriz-Blanco Patricia, Hirt Ann M., Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke
Journal of Magnetism and Magnetic Materials (2019)

Understanding the assembly of amphiphilic additives in bulk and dispersed non-lamellar lipid-based matrices: Phosphorylation, H-bonding and ionisation
Etter Marco F., Dellenbach Daria, Petri-Fink Alke, Rothen-Rutishauser Barbara, Landau Ehud M., Fong Wye-Khay
Journal of Colloid and Interface Science (2019)

Polydopamine nanoparticle doped nanofluid for solar thermal energy collector efficiency increase
Hauser Daniel, Steinmetz Lukas, Balog Sandor, Taladriz‐Blanco Patricia, Septiadi Dedy, Wilts Bodo D., Petri‐Fink Alke, Rothen‐Rutishauser Barbara
Advanced Sustainable Systems (2019)

Heating behavior of magnetic iron oxide nanoparticles at clinically relevant concentration
Lemal Philipp, Balog Sandor, Geers Christoph, Taladriz-Blanco Patricia, Palumbo Andrea, Hirt Ann M., Rothen-Rutishauser Barbara, Petri-Fink Alke
Journal of Magnetism and Magnetic Materials (2019)

Resolution limit of taylor dispersion: An exact theoretical study
Taladriz-Blanco Patricia, Rothen-Rutishauser Barbara, Petri-Fink Alke, Balog Sandor
Analytical Chemistry (2019)

Versatile macroscale concentration gradients of nanoparticles in soft nanocomposites
Taladriz‐Blanco Patricia, Rothen‐Rutishauser Barbara, Petri‐Fink Alke, Balog Sandor
Small (2020)

From bioinspired glue to medicine: Polydopamine as a biomedical material
Hauser Daniel, Septiadi Dedy, Turner Joel, Petri-Fink Alke, Rothen-Rutishauser Barbara
Materials (2020)

Simple and fast evaluation of relaxation parameters of magnetic nanoparticles
Lemal Philipp, Balog Sandor, Ackermann-Hirschi Liliane, Taladriz-Blanco Patricia, Hirt Ann M., Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke
Journal of Magnetism and Magnetic Materials (2020)

Characterization of the shape anisotropy of superparamagnetic iron oxide nanoparticles during thermal decomposition
Vanhecke Dimitri, Crippa Federica, Lattuada Marco, Balog Sandor, Rothen-Rutishauser Barbara, Petri-Fink Alke
Materials (2020)

Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments
Rossier Jeremie, Delasoie Joachim, Haeni Laetitia, Hauser Daniel, Rothen-Rutishauser Barbara, Zobi Fabio
Journal of Inorganic Biochemistry (2020)

Particle surfaces to study macrophage adherence, migration, and clearance
Septiadi Dedy, Lee Aaron, Spuch‐Calvar Miguel, Moore Thomas Lee, Spiaggia Giovanni, Abdussalam Wildan, Rodriguez‐Lorenzo Laura, Taladriz‐Blanco Patricia, Rothen‐Rutishauser Barbara, Petri‐Fink Alke
Advanced Functional Materials (2020)

An inflamed human alveolar model for testing the efficiency of anti-inflammatory drugs in vitro
Drasler Barbara, Karakocak Bedia Begum, Tankus Esma Bahar, Barosova Hana, Abe Jun, Sousa de Almeida Mauro, Petri-Fink Alke, Rothen-Rutishauser Barbara
Frontiers in Bioengineering and Biotechnology (2020)

Rapid and sensitive quantification of cell-associated multi-walled carbon nanotubes
Steinmetz Lukas, Bourquin Joel, Barosova Hana, Haeni Laetitia, Caldwell Jessica, Milosevic Ana, Geers Christoph, Bonmarin Mathias, Taladriz-Blanco Patricia, Rothen-Rutishauser Barbara, Petri-Fink Alke
Nanoscale (2020)

Increased uptake of silica nanoparticles in inflamed macrophages but not upon co-exposure to micron-sized particles
Susnik Eva, Taladriz-Blanco Patricia, Drasler Barbara, Balog Sandor, Petri-Fink Alke, Rothen-Rutishauser Barbara
Cells (2020)

Silica nanoparticles enhance disease resistance in Arabidopsis plants
El-Shetehy Mohamed, Moradi Aboubakr, Maceroni Mattia, Reinhardt Didier, Petri-Fink Alke, Rothen-Rutishauser Barbara, Mauch Felix, Schwab Fabienne
Nature Nanotechnology (2020)

When plants and plastic interact
Schwab Fabienne, Rothen-Rutishauser Barbara, Petri-Fink Alke
Nature Nanotechnology (2020)

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Sousa de Almeida Mauro, Susnik Eva, Drasler Barbara, Taladriz-Blanco Patricia, Petri-Fink Alke, Rothen-Rutishauser Barbara
Chemical Society Reviews (2021)

Experimental and theoretical validation of plasmonic nanoparticle heat generation by using lock-in thermography
Steinmetz Lukas, Geers Christoph, Bonmarin Mathias, Rothen-Rutishauser Barbara, Petri-Fink Alke, Lattuada Marco
The Journal of Physical Chemistry C (2021)

Detection of sub-micro- and nanoplastic particles on gold nanoparticle-based substrates through surface-enhanced raman scattering (SERS) spectroscopy
Caldwell Jessica, Taladriz-Blanco Patricia, Rothen-Rutishauser Barbara, Petri-Fink Alke
Nanomaterials (2021)

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies
Dijkhoff Irini M., Drasler Barbara, Karakocak Bedia Begum, Petri-Fink Alke, Valacchi Giuseppe, Eeman Marc, Rothen-Rutishauser Barbara
Particle and Fibre Toxicology (2020)

Spatial and temporal analysis of meso- and microplastic pollution in the Ligurian and Tyrrhenian Seas
Caldwell Jessica, Muff Livius F., Pham Christopher K., Petri-Fink Alke, Rothen-Rutishauser Barbara, Lehner Roman
Marine Pollution Bulletin (2020)

An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols
Barosova Hana, Karakocak Bedia Begum, Septiadi Dedy, Petri-Fink Alke, Stone Vicki, Rothen-Rutishauser Barbara
International Journal of Molecular Sciences (2020)

Size and Surface Charge Dependent Impregnation of Nanoparticles in Soft- and Hardwood
Bossert David, Geers Christoph, Placencia Peña Maria Inés, Volkmer Thomas, Rothen-Rutishauser Barbara, Petri-Fink Alke
Chemistry (2020)

Innovative preclinical models for pulmonary drug delivery research
Ehrmann Stephan, Schmid Otmar, Darquenne Chantal, Rothen-Rutishauser Barbara, Sznitman Josue, Yang Lin, Barosova Hana, Vecellio Laurent, Mitchell Jolyon, Heuze-Vourc’h Nathalie
Expert Opinion on Drug Delivery (2020)

A hydrofluoric acid-free method to dissolve and quantify silica nanoparticles in aqueous and solid matrices
Bossert David, Urban Dominic A., Maceroni Mattia, Ackermann-Hirschi Liliane, Haeni Laetitia, Yajan Phattadon, Spuch-Calvar Miguel, Rothen-Rutishauser Barbara, Rodriguez-Lorenzo Laura, Petri-Fink Alke, Schwab Fabienne
Scientific Reports (2019)

A Simple Method to Determine Cytotoxicity of Water-Soluble Organic Compounds and Solid Particles from Biomass Combustion in Lung Cells in Vitro
Zotter Peter, Richard Stéphane, Egli Marcel, Rothen-Rutishauser Barbara, Nussbaumer Thomas
Environmental Science & Technology (2019)

Publisher Correction: Subcellular Imaging of Liquid Silicone Coated-Intestinal Epithelial Cells
Nirmalraj Peter, Lehner Roman, Thompson Damien, Rothen-Rutishauser Barbara, Mayer Michael
Scientific Reports (2018)

Air–Liquid InterfaceIn VitroModels for Respiratory Toxicology Research: Consensus Workshop and Recommendations
Lacroix Ghislaine, Koch Wolfgang, Ritter Detlef, Gutleb Arno C., Larsen Søren Thor, Loret Thomas, Zanetti Filippo, Constant Samuel, Chortarea Savvina, Rothen-Rutishauser Barbara, Hiemstra Pieter S., Frejafon Emeric, Hubert Philippe, Gribaldo Laura, Kearns Peter, Aublant Jean-Marc, Diabaté Silvia, Weiss Carsten, de Groot Antoinette, Kooter Ingeborg
Applied In Vitro Toxicology (2018)

Alveolar Epithelium in Lung Toxicology
Chang L.-Y., Crapo J.D., Gehr P., Rothen-Rutishauser B., Mühfeld C., Blank F.
Comprehensive Toxicology (2017)

Identification and Characterization of a Dendritic Cell Precursor in Parenchymal Lung Tissue
von Garnier Christophe, Blank Fabian, Rothen-Rutishauser Barbara, Goethert Joachim R., Holt Patrick G., Stumbles Philip A., Strickland Deborah H.
American Journal of Respiratory Cell and Molecular Biology (2016)

Cellular Shuttles: Monocytes/Macrophages Exhibit Transendothelial Transport of Nanoparticles under Physiological Flow
Moore Thomas L., Hauser Daniel, Gruber Thomas, Rothen-Rutishauser Barbara, Lattuada Marco, Petri-Fink Alke, Lyck Ruth
ACS Applied Materials & Interfaces (2017)

Characteristics and properties of nano-LiCoO2 synthesized by pre-organized single source precursors: Li-ion diffusivity, electrochemistry and biological assessment
Brog Jean-Pierre, Crochet Aurélien, Seydoux Joël, Clift Martin J. D., Baichette Benoît, Maharajan Sivarajakumar, Barosova Hana, Brodard Pierre, Spodaryk Mariana, Züttel Andreas, Rothen-Rutishauser Barbara, Kwon Nam Hee, Fromm Katharina M.
Journal of Nanobiotechnology (2017)

Effects of gasoline and ethanol-gasoline exhaust exposure on human bronchial epithelial and natural killer cells in vitro
Roth Michèle, Usemann Jakob, Bisig Christoph, Comte Pierre, Czerwinski Jan, Mayer Andreas C.R., Beier Konstantin, Rothen-Rutishauser Barbara, Latzin Philipp, Müller Loretta
Toxicology in Vitro (2017)

Human Asthmatic Bronchial Cells Are More Susceptible to Subchronic Repeated Exposures of Aerosolized Carbon Nanotubes At Occupationally Relevant Doses Than Healthy Cells
Chortarea Savvina, Barosova Hana, Clift Martin James David, Wick Peter, Petri-Fink Alke, Rothen-Rutishauser Barbara
ACS Nano (2017)

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials
Clippinger Amy J., Ahluwalia Arti, Allen David, Bonner James C., Casey Warren, Castranova Vincent, David Raymond M., Halappanavar Sabina, Hotchkiss Jon A., Jarabek Annie M., Maier Monika, Polk William, Rothen-Rutishauser Barbara, Sayes Christie M., Sayre Phil, Sharma Monita, Stone Vicki
Archives of Toxicology (2016)

Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs)
Sharma Monita, Nikota Jake, Halappanavar Sabina, Castranova Vincent, Rothen-Rutishauser Barbara, Clippinger Amy J.
Archives of Toxicology (2016)

Articular cartilage: from formation to tissue engineering
Camarero-Espinosa Sandra, Rothen-Rutishauser Barbara, Foster E. Johan, Weder Christoph
Biomaterials Science (2016)

Formation of drug nanocrystals under nanoconfinement afforded by liposomes
Cipolla D., Wu H., Salentinig S., Boyd B., Rades T., Vanhecke D., Petri-Fink A., Rothin-Rutishauser B., Eastman S., Redelmeier T., Gonda I., Chan H. K.
RSC Advances (2016)

Investigating the role of shape on the biological impact of gold nanoparticles in vitro
Tian Furong, Clift Martin JD, Casey Alan, del Pino Pablo, Pelaz Beatriz, Conde João, Byrne Hugh J, Rothen-Rutishauser Barbara, Estrada Giovani, de la Fuente Jesús M, Stoeger Tobias
Nanomedicine (2015)

Microfluidic platforms for advanced risk assessments of nanomaterials
Mahto Sanjeev Kumar, Charwat Verena, Ertl Peter, Rothen-Rutishauser Barbara, Rhee Seog Woo, Sznitman Josué
Nanotoxicology (2014)

Biomimetics of fetal alveolar flow phenomena using microfluidics
Tenenbaum-Katan Janna, Fishler Rami, Rothen-Rutishauser Barbara, Sznitman Josué
Biomicrofluidics (2015)

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices
Hirn Stephanie, Haberl Nadine, Loza Kateryna, Epple Matthias, Kreyling Wolfgang G, Rothen-Rutishauser Barbara, Rehberg Markus, Krombach Fritz
Beilstein Journal of Nanotechnology (2014)

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments
Ahlberg Sebastian, Antonopulos Alexandra, Diendorf Jörg, Dringen Ralf, Epple Matthias, Flöck Rebekka, Goedecke Wolfgang, Graf Christina, Haberl Nadine, Helmlinger Jens, Herzog Fabian, Heuer Frederike, Hirn Stephanie, Johannes Christian, Kittler Stefanie, Köller Manfred, Korn Katrin, Kreyling Wolfgang G, Krombach Fritz, Lademann Jürgen, Loza Kateryna, Luther Eva M, Malissek Marcelina, Meinke Martina C, Nordmeyer Daniel, Pailliart Anne, Raabe Jörg, Rancan Fiorenza, Rothen-Rutishauser Barbara, Rühl Eckart, Schleh Carsten, Seibel Andreas, Sengstock Christina, Treuel Lennart, Vogt Annika, Weber Katrin, Zellner Reinhard
Beilstein Journal of Nanotechnology (2014)

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
Alépée Natalie
ALTEX (2014)

The choice of nanoparticle surface coupled fluorescent dyes impacts cellular interaction
Milosevic Ana M, Haeni Laetitia, Ackermann Liliane, Campomanes-Ramos Pablo, Vanni Stefano, Rothen-Rutishauser Barbara, Rodriguez-Lorenzo Laura, Fink Alke Susanne
ChemNanoMat (2021)

Impurities in polyvinylpyrrolidone: the key factor in the synthesis of gold nanostars
Taladriz-Blanco Patricia, Spuch-Calvar Miguel, Prado Anselmo del, Weder Christoph, Rother-Rutishauser Barbara, Petri-Fink Alke, Rodriguez-Lorenzo Laura
Nanoscale Advances (2021)

Cellular Uptake of Silica and Gold Nanoparticles Induces Early Activation of Nuclear Receptor NR4A1
Sousa de Almeida Mauro, Taladriz-Blanco Patricia, Drasler Barbara, Balog Sandor, Yajan Phattadon, Petri-Fink Alke, Rothen-Rutishauser Barbara
Nanomaterials (2022)

The micro-, submicron-, and nanoplastic hunt: A review of detection methods for plastic particles
Caldwell Jessica, Taladriz-Blanco Patricia, Lehner Roman, Lubskyy Andriy, Ortuso Roberto Diego, Rothen-Rutishauser Barbara, Petri-Fink Alke
Chemosphere (2022)

Polymersomes‐mediated Delivery of CSF1R Inhibitor to Tumor Associated Macrophages Promotes M2 to M1‐like Macrophage Repolarization
Rodriguez‐Perdigon Manuel, Jimaja Sètuhn, Haen Laetitia, Bruns Nico, Rothen‐Rutishauser Barbara, Rüegg Curzio
Macromolecular Bioscience (2022)

Intracellular gold nanoparticles influence light scattering and facilitate amplified spontaneous emission generation
Yajan Phattadon, Yulianto Nursidik, Saba Matthias, Dharmawan Agus Budi, Sousa de Almeida Mauro, Taladriz-Blanco Patricia, Wasisto Hutomo Suryo, Rothen-Rutishauser Barbara, Petri-Fink Alke, Septiadi Dedy
Journal of Colloid and Interface Science (2022)

Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells
Sousa de Almeida Mauro, Rothen-Rutishauser Barbara, Mayer Michael, Taskova Maria
Biomedicines (2022)

Designing the ultrasonic treatment of nanoparticle-dispersions via machine learning
Glaubitz Christina, Rothen-Rutishauser Barbara, Lattuada Marco, Balog Sandor, Petri-Fink Alke
Nanoscale (2022)

Substrate stiffness reduces particle uptake by epithelial cells and macrophages in a size-dependent manner through mechanoregulation
Lee Aaron, Sousa de Almeida Mauro, Milinkovic Daela, Septiadi Dedy, Taladriz-Blanco Patricia, Loussert-Fonta Céline, Balog Sandor, Bazzoni Amelie, Rothen-Rutishauser Barbara, Petri-Fink Alke
Nanoscale (2022)

Encapsulated salts in velvet worm slime drive its hardening
Corrales-Ureña Yendry Regina, Schwab Fabienne, Ochoa-Martínez Efraín, Benavides-Acevedo Miguel, Vega-Baudrit José, Pereira Reinaldo, Rischka Klaus, Noeske Paul-Ludwig Michael, Gogos Alexander, Vanhecke Dimitri, Rothen-Rutishauser Barbara, Petri-Fink Alke
Scientific Reports (2022)

Pitfalls in methods to study colocalization of nanoparticles in mouse macrophage lysosomes
Moreno-Echeverri Aura Maria, Susnik Eva, Vanhecke Dimitri, Taladriz-Blanco Patricia, Balog Sandor, Petri-Fink Alke, Rothen-Rutishauser Barbara
Journal of Nanobiotechnology (2022)

Layer-by-Layer siRNA Particle Assemblies for Localized Delivery of siRNA to Epithelial Cells through Surface-Mediated Particle Uptake
Lee Aaron, Gosnell Natalia, Milinkovic Daela, Taladriz-Blanco Patricia, Rothen-Rutishauser Barbara, Petri-Fink Alke
ACS Applied Bio Materials (2023)

Cellular Uptake of Silica Particles Influences EGFR Signaling Pathway and is Affected in Response to EGF
Sousa de Almeida Mauro, Roshanfekr Arya, Balog Sandor, Petri-Fink Alke, Rothen-Rutishauser Barbara
International Journal of Nanomedicine (2023)

The Influence of Liquid Menisci on Nanoparticle Dosimetry in Submerged Cells
Glaubitz Christina, Haeni Laetitia, Sušnik Eva, Rothen‐Rutishauser Barbara, Balog Sandor, Petri‐Fink Alke
Small (2023)

The Functions of Cholera Toxin Subunit B as a Modulator of Silica Nanoparticle Endocytosis
Susnik Eva, Balog Sandor, Taladriz-Blanco Patricia, Petri-Fink Alke, Rothen-Rutishauser Barbara
Toxins (2023)

Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2+ breast cancer spheroid model
Rodriguez-Perdigon Manuel, Haeni Laetitia, Rothen-Rutishauser Barbara, Rüegg Curzio
Frontiers in Bioengineering and Biotechnology (2023)

Submicron- and nanoplastic detection at low micro- to nanogram concentrations using gold nanostar-based surface-enhanced Raman scattering (SERS) substrates
Caldwell Jessica, Taladriz-Blanco Patricia, Rodriguez-Lorenzo Laura, Rothen-Rutishauser Barbara, Petri-Fink Alke
Environmental Science: Nano (2023)

Immunostimulatory nanoparticles delivering cytokines as a novel cancer nanoadjuvant to empower glioblastoma immunotherapy
Sousa Flávia, Lee Henry, Almeida Mauro, Bazzoni Amelie, Rothen-Rutishauser Barbara, Petri-Fink Alke
Drug Delivery and Translational Research (2023)

Leveraging Machine Learning for Size and Shape Analysis of Nanoparticles: A Shortcut to Electron Microscopy
Glaubitz Christina, Bazzoni Amélie, Ackermann-Hirschi Liliane, Baraldi Laura, Haeffner Moritz, Fortunatus Roman, Rothen-Rutishauser Barbara, Balog Sandor, Petri-Fink Alke
The Journal of Physical Chemistry C (2023)

The Effect of Substrate Properties on Cellular Behavior and Nanoparticle Uptake in Human Fibroblasts and Epithelial Cells
Sousa de Almeida Mauro, Lee Aaron, Itel Fabian, Maniura-Weber Katharina, Petri-Fink Alke, Rothen-Rutishauser Barbara
Nanomaterials (2024)

Does the surface charge of the nanoparticles drive nanoparticle–cell membrane interactions?
Balog Sandor, de Almeida Mauro Sousa, Taladriz-Blanco Patricia, Rothen-Rutishauser Barbara, Petri-Fink Alke
Current Opinion in Biotechnology (2024)

The impact of macrophage phenotype and heterogeneity on the total internalized gold nanoparticle counts
Lee Henry, Vanhecke Dimitri, Balog Sandor, Taladriz-Blanco Patricia, Petri-Fink Alke, Rothen-Rutishauser Barbara
Nanoscale Advances (2024)

Understanding Macrophage Interaction with Antimony-Doped Tin Oxide Plasmonic Nanoparticles
Balitskii Olexiy, Ivasiv Viktoriya, Porteiro-Figueiras Maria, Yajan Phattadon, Witzig Mira, Moreno-Echeverri Aura Maria, Muñetón Díaz José, Rothen-Rutishauser Barbara, Petri-Fink Alke, Keshavan Sandeep
Cells (2024)

The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients
Di Stolfo Luigi, Lee Wang Sik, Vanhecke Dimitri, Balog Sandor, Taladriz-Blanco Patricia, Petri-Fink Alke, Rothen-Rutishauser Barbara
Frontiers in Bioengineering and Biotechnology (2025)

Intermolecular Dynamics of Monoglyceride Mesophases with Their Biomacromolecular Corona
Fong Wye-Khay, Vanhecke Dimitri, Hauser Daniel, Balog Sandor, Lemal Philipp, Montasseri Shiva, Rothen-Rutishauser Barbara, Petri-Fink Alke
Molecular Pharmaceutics (2025)

Beating-wave analysis of small-angle X-ray scattering of unilamellar liposomes loaded with model drug Benzocaine
Baraldi Laura, Alfarano Serena R., Sousa Flávia, Marchiò Luciano, Bacchi Alessia, Mezzenga Raffaele, Rothen-Rutishauser Barbara, Petri-Fink Alke, Balog Sandor
Nanoscale (2025)

ROTHEN Barbara

NanoRoomba: Cellular uptake and durotaxis on ‘’soft and rigid‘’ nanoparticle carpet

Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

Magneto-responsive cell culture substrates that can be modulated in situ

Intelligent nanomaterials to reveal and control their behavior in complex media, at biointerface and in cells

Development of Tumor/Immune Cell Organoid Model

Characterizing nanoparticle-membrane interactions via molecular dynamics simulations

Fluorescent nanodiamonds as quantum bio-molecular probes for live cell imaging and sensing

Mechanically responsive and mechanically adapting polymers

Novel antiviral supramolecular materials

Self-assembly of DNA- or RNA-triggered ion channels for targeted cell killing and nanopore sensing

Trapping cancer cells with self-assembling biomolecules

Mechanically responsive nanoparticles

Development of a Microfluidic Platform

Development of controlled delivery systems for organ-on-chip devices

Nature-inspired nano-interfaces for triggering lipid digestion

Dynamic surfaces for tissue engineering and tissue remodeling

Antiviral Surfaces

Antimicrobial surfaces