Person | Bioinspired Materials NCCR | Université de Fribourg

LUTOLF Matthias

Professor, Research group LUTOLF

Laboratory of Stem Cell Bioengineering EPFL - SV- IBI - LSCB Station 15 Bld. AI 1106 CH-1015 Lausanne Switzerland

Email:	matthias.lutolf@epfl.ch
Website:	https://lscb.epfl.ch/

Projects lead

Steering tissue morphogenesis via stimuli-sensitive hydrogels

Using engineered microenvironments to control the development of stem cells into organoids

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Development of a Microfluidic Platform

Development of a Microfluidic Organoid Culture Platform

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Projects team

Development of Tumor/Immune Cell Organoid Model

A tumoroid culture system to study the role of inflammation in cancer dormancy vs progression

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3D printing of functional organoids using viscoelastic capsules

Towards the stable room temperature printing of organoid-forming stem cells

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Publications

Bioinspired hydrogels for 3D organoid culture
Blondel Delphine, Lutolf Matthias P.
CHIMIA International Journal for Chemistry (2019)

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells
Manfrin Andrea, Tabata Yoji, Paquet Eric R., Vuaridel Ambroise R., Rivest François R., Naef Felix, Lutolf Matthias P.
Nature Methods (2019)

Low‐defect thiol‐Michael addition hydrogels as matrigel substitutes for epithelial organoid derivation
Rezakhani Saba, Gjorevski Nikolce, Lutolf Matthias P.
Advanced Functional Materials (2020)

Hydrogel-based milliwell arrays for standardized and scalable retinal organoid cultures
Decembrini S., Hoehnel S., Brandenberg N., Arsenijevic Y., Lutolf M. P.
Scientific Reports (2020)

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis
Nikolaev Mikhail, Mitrofanova Olga, Broguiere Nicolas, Geraldo Sara, Dutta Devanjali, Tabata Yoji, Elci Bilge, Brandenberg Nathalie, Kolotuev Irina, Gjorevski Nikolce, Clevers Hans, Lutolf Matthias P.
Nature (2020)

Recapitulating macro-scale tissue self-organization through organoid bioprinting
Brassard Jonathan A., Nikolaev Mike, Hübscher Tania, Hofer Moritz, Lutolf Matthias P.
Nature Materials (2020)

Stem-cell-based embryo models for fundamental research and translation
Fu Jianping, Warmflash Aryeh, Lutolf Matthias P.
Nature Materials (2020)

Engineering organoids
Hofer Moritz, Lutolf Matthias P.
Nature Reviews Materials (2021)

Bioengineering in vitro models of embryonic development
Gupta Ananya, Lutolf Matthias P., Hughes Alex J., Sonnen Katharina F.
Stem Cell Reports (2021)

Synthetic dynamic hydrogels promote degradation-independent in vitro organogenesis
Chrisnandy Antonius, Blondel Delphine, Rezakhani Saba, Broguiere Nicolas, Lutolf Matthias P.
Nature Materials (2021)

Bioengineered embryoids mimic post-implantation development in vitro
Girgin Mehmet U., Broguiere Nicolas, Hoehnel Sylke, Brandenberg Nathalie, Mercier Bastien, Arias Alfonso Martinez, Lutolf Matthias P.
Nature Communications (2021)

Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution
Rossi Giuliana, Giger Sonja, Hübscher Tania, Lutolf Matthias P.
Scientific Reports (2022)

A New Approach to Generate Gastruloids to Develop Anterior Neural Tissues
Girgin Mehmet, Broguiere Nicolas, Mattolini Lorenzo, Lutolf Matthias
BIO-PROTOCOL (2023)

LUTOLF Matthias

Steering tissue morphogenesis via stimuli-sensitive hydrogels

Development of a Microfluidic Platform

Development of Tumor/Immune Cell Organoid Model

3D printing of functional organoids using viscoelastic capsules