Person | Bioinspired Materials NCCR | Université de Fribourg

BRUNS Nico

Professor, Research group BRUNS

Chemistry department TU Darmstadt Alarich-Weiss-Straße 4 64287 Darmstadt Germany

Office:	TG507
Phone:	+44 (0)141 548 4648
Email:	nico.bruns@tu-darmstadt.de
Website:	https://bruns-lab.com/
	0000-0001-6199-9995

Projects lead

Mechanically responsive block copolymer nanoreactors inspired by the marine bioluminescence of dinoflagellates

Mastering biochemical reactions inside mechanically responsive vesicles

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Development of cargo carriers

Compartmentalized systems to deliver morphogenetic factors

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Projects team

Mechanically responsive and mechanically adapting polymers

Reducing the activation stress threshold of mechanoresponsive materials

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Mechano-responsive CaCO3-based coatings

Understanding how the processing conditions of CaCO3 influence the properties of derived composite materials

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Mechanoresponsive materials enabled by 3D Printing and high-throughput microfluidics

Mimicking Nature's mechanisms for controlled multimaterial growth

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Development of Tumor/Immune Cell Organoid Model

A tumoroid culture system to study the role of inflammation in cancer dormancy vs progression

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Ion-selective membranes for power conversion from salinity gradients with unprecedented efficiency

Electric eel-inspired materials to storage and deliver electrical power

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Transiently pulsating materials inspired by the heart

Replicating the responsiveness of living systems with an artificial, out-of-equilibrium autonomous system

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Publications

Self-reporting fiber-reinforced composites that mimic the ability of biological materials to sense and report damage
Rifaie-Graham Omar, Apebende Edward A., Bast Livia K., Bruns Nico
Advanced Materials (2018)

Structural behavior of cylindrical polystyrene-block -Poly(ethylene-butylene)-block -Polystyrene (SEBS) triblock copolymer containing MWCNTs: On the influence of nanoparticle surface modification
Hasanabadi Noushin, Nazockdast Hossein, Gajewska Bernadetta, Balog Sandor, Gunkel Ilja, Bruns Nico, Lattuada Marco
Macromolecular Chemistry and Physics (2017)

Visible light-responsive DASA-polymer conjugates
Ulrich Sebastian, Hemmer James R., Page Zachariah A., Dolinski Neil D., Rifaie-Graham Omar, Bruns Nico, Hawker Craig J., Boesel Luciano F., Read de Alaniz Javier
ACS Macro Letters (2017)

Wavelength-selective light-responsive DASA-functionalized polymersome nanoreactors
Rifaie-Graham Omar, Ulrich Sebastian, Galensowske Nikolas F. B., Balog Sandor, Chami Mohamed, Rentsch Daniel, Hemmer James R., Read de Alaniz Javier, Boesel Luciano F., Bruns Nico
Journal of the American Chemical Society (2018)

Laccase-catalyzed controlled radical polymerization of N-vinylimidazole
Fodor Csaba, Gajewska Bernadetta, Rifaie-Graham Omar, Apebende Edward A., Pollard Jonas, Bruns Nico
Polymer Chemistry (2016)

Protein cages and synthetic polymers: a fruitful symbiosis for drug delivery applications, bionanotechnology and materials science
Rother Martin, Nussbaumer Martin G., Renggli Kasper, Bruns Nico
Chemical Society Reviews (2016)

Filling polymersomes with polymers by peroxidase-catalyzed atom transfer radical polymerization
Dinu Maria Valentina, Spulber Mariana, Renggli Kasper, Wu Dalin, Monnier Christophe A., Petri-Fink Alke, Bruns Nico
Macromolecular Rapid Communications (2015)

Chapter 11. Self-reporting polymeric materials with mechanochromic properties

(2016)

Effects of silk degumming process on physicochemical, tensile, and optical properties of regenerated silk fibroin
Nultsch Kira, Bast Livia K., Näf Muriel, Yakhlifi Salima El, Bruns Nico, Germershaus Oliver
Macromolecular Materials and Engineering (2018)

Bio-inspired polymersome nanoreactors
Rifaie-Graham Omar, Apebende Edward A., Bruns Nico
CHIMIA International Journal for Chemistry (2019)

Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis
Rifaie-Graham Omar, Pollard Jonas, Raccio Samuel, Balog Sandor, Rusch Sebastian, Hernández-Castañeda María Andrea, Mantel Pierre-Yves, Beck Hans-Peter, Bruns Nico
Nature Communications (2019)

Light-responsive block copolymers with a spiropyran located at the block junction
Apebende Edward A., Dubois Laurent, Bruns Nico
European Polymer Journal (2019)

Biocatalytically initiated precipitation atom transfer radical polymerization (ATRP) as a quantitative method for hemoglobin detection in biological fluids
Pollard Jonas, Rifaie-Graham Omar, Raccio Samuel, Davey Annabelle, Balog Sandor, Bruns Nico
Analytical Chemistry (2019)

Rapid quantification of the malaria biomarker hemozoin by improved biocatalytically initiated precipitation atom transfer radical polymerizations
Raccio Samuel, Pollard Jonas, Djuahdi Ashley, Balog Sandor, Pellizzoni Michela M., Rodriguez Kyle Joel, Rifaie-Graham Omar, Bruns Nico
The Analyst (2020)

Shear stress‐responsive polymersome nanoreactors inspired by the marine bioluminescence of dinoflagellates
Rifaie-Graham Omar, Galensowske Nikolas F.B., Dean Charlie, Pollard Jonas, Balog Sandor, Gouveia Micael G., Chami Mohamed, Vian Antoine, Amstad Esther, Lattuada Marco, Bruns Nico
Angewandte Chemie International Edition (2020)

Infiltration of proteins in cholesteric cellulose structures
Bast Livia K., Klockars Konrad W., Greca Luiz G., Rojas Orlando J., Tardy Blaise L., Bruns Nico
Biomacromolecules (2021)

Shear Stress‐Responsive Polymersome Nanoreactors Inspired by the Marine Bioluminescence of Dinoflagellates
Rifaie‐Graham Omar, Galensowske Nikolas F. B., Dean Charlie, Pollard Jonas, Balog Sandor, Gouveia Micael G., Chami Mohamed, Vian Antoine, Amstad Esther, Lattuada Marco, Bruns Nico
Angewandte Chemie (2020)

Nano‐3D‐Printed Photochromic Micro‐Objects
Ulrich Sebastian, Wang Xiaopu, Rottmar Markus, Rossi René Michel, Nelson Bradley J., Bruns Nico, Müller Ralph, Maniura‐Weber Katharina, Qin Xiao‐Hua, Boesel Luciano Fernandes
Small (2021)

A Methodology for Remote Microwave Sterilization Applicable to the Coronavirus and Other Pathogens using Retrodirective Antenna Arrays
Kossenas Konstantinos, Podilchak Symon K., Comite Davide, Hilario Re Pascual D., Goussetis George, Pavuluri Sumanth Kumar, Griffiths Samantha, Chadwick Robert, Guo Chao, Bruns Nico, Burkard Christine, Haas Juergen, Desmulliez Marc
IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology (2021)

Promoting the Furan Ring‐Opening Reaction to Access New Donor–Acceptor Stenhouse Adducts with Hexafluoroisopropanol
Clerc Michèle, Stricker Friedrich, Ulrich Sebastian, Sroda Miranda, Bruns Nico, Boesel Luciano F., Read de Alaniz Javier
Angewandte Chemie (2021)

Promoting the Furan Ring‐Opening Reaction to Access New Donor–Acceptor Stenhouse Adducts with Hexafluoroisopropanol
Clerc Michèle, Stricker Friedrich, Ulrich Sebastian, Sroda Miranda, Bruns Nico, Boesel Luciano F., Read de Alaniz Javier
Angewandte Chemie International Edition (2021)

Stabilizing Enzymes within Polymersomes by Coencapsulation of Trehalose
Dinu Maria Valentina, Dinu Ionel Adrian, Saxer Sina S., Meier Wolfgang, Pieles Uwe, Bruns Nico
Biomacromolecules (2020)

Silk Sericin-Polylactide Protein–Polymer Conjugates as Biodegradable Amphiphilic Materials and Their Application in Drug Release Systems
Boonpavanitchakul Kanittha, Bast Livia K., Bruns Nico, Magaraphan Rathanawan
Bioconjugate Chemistry (2020)

CHAPTER 15. Functional Membranes Based on Amphiphilic Polymer Co-networks
Ulrich Sebastian, Boesel Luciano F., Bruns Nico
Polymer Chemistry Series (2020)

Tuning the Properties of a UV-Polymerized, Cross-Linked Solid Polymer Electrolyte for Lithium Batteries
Sutton Preston, Airoldi Martino, Porcarelli Luca, Olmedo-Martínez Jorge L., Mugemana Clément, Bruns Nico, Mecerreyes David, Steiner Ullrich, Gunkel Ilja
Polymers (2020)

Self‐Healing Metallo‐Supramolecular Amphiphilic Polymer Conetworks
Mugemana Clément, Grysan Patrick, Dieden Reiner, Ruch David, Bruns Nico, Dubois Philippe
Macromolecular Chemistry and Physics (2020)

Virtual special issue “Biomimetic Polymers”
Bruns Nico, Scheibel Thomas
European Polymer Journal (2019)

Pyranine‐Modified Amphiphilic Polymer Conetworks as Fluorescent Ratiometric pH Sensors
Ulrich Sebastian, Osypova Alina, Panzarasa Guido, Rossi René M., Bruns Nico, Boesel Luciano F.
Macromolecular Rapid Communications (2019)

Biocatalytic ATRP in solution and on surfaces
Rodriguez Kyle J., Pellizzoni Michela M., Divandari Mohammad, Benetti Edmondo M., Bruns Nico
Methods in Enzymology (2019)

Enzyme-initiated free radical polymerizations of vinyl monomers using horseradish peroxidase
Rodriguez Kyle J., Pellizzoni Michela M., Chadwick Robert J., Guo Chao, Bruns Nico
Methods in Enzymology (2019)

Preface
Bruns Nico, Loos Katja
Methods in Enzymology (2019)

Light-responsive block copolymers with a spiropyran located at the block junction
Apebende Edward A., Dubois Laurent, Bruns Nico
European Polymer Journal (2019)

Bio-Inspired Polymersome Nanoreactors
Rifaie-Graham Omar, Apebende Edward A., Bruns Nico
CHIMIA International Journal for Chemistry (2019)

Chlorophyll derivatives as catalysts and comonomers for atom transfer radical polymerizations
Gajewska Bernadetta, Raccio Samuel, Rodriguez Kyle J., Bruns Nico
Polymer Chemistry (2018)

Repurposing Biocatalysts to Control Radical Polymerizations
Rodriguez Kyle J., Gajewska Bernadetta, Pollard Jonas, Pellizzoni Michela M., Fodor Csaba, Bruns Nico
ACS Macro Letters (2018)

DNA-Coated Functional Oil Droplets
Caciagli Alessio, Zupkauskas Mykolas, Levin Aviad, Knowles Tuomas P. J., Mugemana Clément, Bruns Nico, O’Neill Thomas, Frith William J., Eiser Erika
Langmuir (2018)

Biocatalytic ATRP
Pollard Jonas, Bruns Nico
ACS Symposium Series (2018)

Wide Range of Functionalized Poly(N-alkyl acrylamide)-Based Amphiphilic Polymer Conetworks via Active Ester Precursors
Ulrich Sebastian, Sadeghpour Amin, Rossi René M., Bruns Nico, Boesel Luciano F.
Macromolecules (2018)

Bioinspired Materials: (Adv. Mater. 19/2018)

Advanced Materials (2018)

Controlling Enzymatic Polymerization from Surfaces with Switchable Bioaffinity
Divandari Mohammad, Pollard Jonas, Dehghani Ella, Bruns Nico, Benetti Edmondo M.
Biomacromolecules (2017)

Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor
Renggli Kasper, Sauter Nora, Rother Martin, Nussbaumer Martin G., Urbani Raphael, Pfohl Thomas, Bruns Nico
Polymer Chemistry (2017)

Bio-inspired Polymers

Polymer Chemistry Series (2016)

Preface

Polymer Chemistry Series (2016)

Chaperonin–Dendrimer Conjugates for siRNA Delivery
Nussbaumer Martin G., Duskey Jason T., Rother Martin, Renggli Kasper, Chami Mohamed, Bruns Nico
Advanced Science (2016)

Using the dendritic polymer PAMAM to form gold nanoparticles in the protein cage thermosome
Nussbaumer Martin G., Bisig Christoph, Bruns Nico
Chemical Communications (2016)

Self-Sealing and Puncture Resistant Breathable Membranes for Water-Evaporation Applications
Rother Martin, Barmettler Jonas, Reichmuth Andreas, Araujo Jose V., Rytka Christian, Glaied Olfa, Pieles Uwe, Bruns Nico
Advanced Materials (2015)

Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery
Toughraï Smahan, Malinova Violeta, Masciadri Raffaello, Menon Sindhu, Tanner Pascal, Palivan Cornelia, Bruns Nico, Meier Wolfgang
Macromolecular Bioscience (2015)

Polymeric Particulates for Subunit Vaccine Delivery
Schuster Thomas, Nussbaumer Martin, Baumann Patric, Bruns Nico, Meier Wolfgang, Car Anja
Advances in Delivery Science and Technology (2014)

From Membrane to Skin: Aqueous Permeation Control Through Light-Responsive Amphiphilic Polymer Co-Networks
Schöller Katrin, Küpfer Sabrina, Baumann Lukas, Hoyer Patrick M., de Courten Damien, Rossi René M., Vetushka Aliaksei, Wolf Martin, Bruns Nico, Scherer Lukas J.
Advanced Functional Materials (2014)

pH-Responsive PDMS-b-PDMAEMA Micelles for Intracellular Anticancer Drug Delivery
Car Anja, Baumann Patric, Duskey Jason T., Chami Mohamed, Bruns Nico, Meier Wolfgang
Biomacromolecules (2014)

Polymersomes‐mediated Delivery of CSF1R Inhibitor to Tumor Associated Macrophages Promotes M2 to M1‐like Macrophage Repolarization
Rodriguez‐Perdigon Manuel, Jimaja Sètuhn, Haen Laetitia, Bruns Nico, Rothen‐Rutishauser Barbara, Rüegg Curzio
Macromolecular Bioscience (2022)

Peptide‐Reinforced Amphiphilic Polymer Conetworks
Velasquez Sara T. R., Jang Daseul, Jenkins Peter, Liu Peng, Yang Liu, Korley LaShanda T. J., Bruns Nico
Advanced Functional Materials (2022)

Polymersome-based protein drug delivery – quo vadis?
Gouveia Micael G., Wesseler Justus P., Ramaekers Jobbe, Weder Christoph, Scholten Philip B. V., Bruns Nico
Chemical Society Reviews (2022)

Rendering Polyurethane Hydrophilic for Efficient Cellulose Reinforcement in Melt‐Spun Nanocomposite Fibers
Redondo Alexandre, Bast Livia K., Djeghdi Kenza, Airoldi Martino, Jang Daseul, Korley LaShanda T. J., Steiner Ullrich, Bruns Nico, Gunkel Ilja
Advanced Materials Interfaces (2023)

Donor–acceptor Stenhouse adduct functionalised polymer microspheres
Wesseler Justus P., Cameron Grant M., Cormack Peter A. G., Bruns Nico
Polymer Chemistry (2023)

Encapsulation of Fragrances in Micro‐ and Nanocapsules, Polymeric Micelles and Polymersomes ^†
Russell Sam, Bruns Nico
Macromolecular Rapid Communications (2023)

Artificial cell synthesis using biocatalytic polymerization-induced self-assembly
Belluati Andrea, Jimaja Sètuhn, Chadwick Robert J., Glynn Christopher, Chami Mohamed, Happel Dominic, Guo Chao, Kolmar Harald, Bruns Nico
Nature Chemistry (2023)

BRUNS Nico

Mechanically responsive block copolymer nanoreactors inspired by the marine bioluminescence of dinoflagellates

Development of cargo carriers

Mechanically responsive and mechanically adapting polymers

Mechano-responsive CaCO3-based coatings

Mechanoresponsive materials enabled by 3D Printing and high-throughput microfluidics

Development of Tumor/Immune Cell Organoid Model

Ion-selective membranes for power conversion from salinity gradients with unprecedented efficiency

Transiently pulsating materials inspired by the heart